Immune or autoimmune?

Inflammatory Bowel Disease: Autoimmune or Immune-mediated Pathogenesis?

The pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), is still unclear, but both autoimmune and immune-mediated phenomena are involved. Autoimmune phenomena include the presence of serum and mucosal autoantibodies against intestinal epithelial cells in either form of IBD, and against human tropomyosin fraction five selectiv...

Immune and Autoimmune Enteropathies

Autoimmune enteropathy characteristically presents in infancy with protracted diarrhea. Underlying disorders of immune function, including regulatory T cells, must be excluded. Treatment options include nutritional rehabilitation, immune suppression, and, in select cases, bone marrow transplant. Copyright © 2006 Nestec Ltd., Vevey/S. Karger AG, Basel

Autoimmune Pancreatitis: An Autoimmune or Immunoinflammatory Disease?

Autoimmune pancreatitis (AIP) has been widely presumed to be an autoimmune disease that is characterized by elevated IgG and/or IgG4, the presence of autoantibodies, and an infiltration of lymphocytes and plasma cells with fibrosis. However, no detailed immunological studies have been published. To define immunological changes in AIP in detail, and to review evidence for autoimmunity which may ...

CD47 is expressed at normal levels in patients with autoimmune haemolytic anaemia and/or immune thrombocytopenia.

CD47 deficiency results in lethal autoimmune haemolytic anaemia (AIHA) and mild spontaneous thrombocytopenia in non-obese diabetic mice. It is unknown whether CD47 has an impact on AIHA of the warm type or autoimmune thrombocytopenia (ITP) in humans. Healthy blood donors (n= 11), patients with AIHA (n= 13), patients with ITP (n= 18) and one patient with Rh(null) phenotype were investigated. CD4...

The Immune System and Autoimmune Diseases